318-336 S. Main Street was built in late 1893 after the “great fire” of 1893 eliminated most of the block. This is the Penniman Building, one of the most recognized structures in town which was built by Kate Penniman-Allen who was a very prominent figure in Plymouth. She was the Daughter of Ebenezer Penniman who was Plymouth’s first Congressman. Some of the most notable businesses in this building are Wiltse’s community pharmacy which has provided some of the best hometown service to this community for most of the 20th Century, 336 Main is a popular Martini Bar ( www.336Main.com ) and there are some great confections cooking at the Cupcake Station.
PlymouthMiDiscoveries 
Unfortunately, Wiltse’s Pharmacy is closing shop in Spring of 2022 after 108 years serving the Plymouth community (seen above at 330 S. Main). Dale and Andrea Knab who’ve owned the pharmacy since 1980, are retiring and the building has been sold seeking new tenants.